The role of CBD in the management of ischemia

What is CBD? Cannabidiol, more commonly known as CBD, is one of several chemical compounds, called cannabinoids, found in the cannabis plant. Unlike THC, which is the main psychoactive in cannabis, CBD does not have an intoxicating effect. In recent years, CBD has gained popularity due to its potential therapeutic properties, supported by scientific studies.

Understanding Ischemia Ischemia is a medical condition characterized by a reduction in blood supply to a part of the body, caused by a blockage in the arteries. This decreased blood flow deprives tissues and organs of essential oxygen and nutrients, which can lead to cellular damage. In severe conditions, ischemia can lead to tissue death, known as necrosis.

CBD and its neuroprotective effects Studies have shown that CBD has neuroprotective properties, particularly during ischemic events. These effects are due to CBD's ability to reduce excitotoxicity (damage caused by overactivation of neurons), oxidative stress (damage caused by free radicals), and inflammation. These mechanisms of action are partly mediated by CB2 and 5-HT1A receptors, which are activated by CBD 1 .

Reduction of infarct size with CBD In animal models of ischemia-reperfusion, CBD has been shown to reduce infarct size. This means that CBD can potentially limit the damage caused by a lack of oxygen in the tissues. Additionally, CBD has shown anti-inflammatory effects, attenuating lipid peroxidation and reducing levels of glutathione, an antioxidant essential for cellular protection 2 .

Testimonials and Advice Many patients have reported improvements after using CBD products to manage their ischemic symptoms. While these testimonials are valuable, it is crucial to consult a medical professional before using CBD for medical conditions. Also be sure to choose quality CBD products to ensure their effectiveness and safety.

References :

“From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology”, Alessia Ligresti, Luciano De Petrocellis, and Vincenzo Di Marzo

A. KICMAN, M. TOCZEK
The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease
International Journal of Molecular Sciences 21:6740 (2020)